Discontinue chronic warfarin therapy 4-5 days before spinal procedure and evaluate INR. INR should be within the normal range at time of procedure to ensure adequate levels of all vitamin K-dependent factors.
No contraindications with aspirin or non-steroidal anti-inflammatory drugs (NSAID). Thienopyridine derivatives (clopidogrel and ticlopidine) should be discontinued 7 days and 14 days, respectively, prior to procedure.
Discontinue to allow recovery of platelet function prior to procedure (8 hours for tirofiban and eptifibatide, 24-48 hours for abciximab).
There are no available data to suggest a safe interval between procedure and initiation or discontinuation of these medications. Follow fibrinogen level and observe for signs of neural compression.
Delay procedure at least 12 hours from the last dose of thromboprophylaxis LMWH dose. For "treatment" dosing of LMWH, at least 24 hours should elapse prior to procedure. LMWH should not be administered within 24 hours after the procedure.
There are no contraindications to neuraxial procedure if total daily dose is less than 10,000 units. For higher dosing regimens, manage according to intravenous heparin guidelines.
Delay spinal puncture 2-4 hours after last dose, document normal aPTT. Heparin may be restarted 1 hour following procedure.